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CDS: SCO2785, SCC105.16, desD
Gene:SCO2785
Pritag:CDS
Start:3038895
End:3040682
Strand:1
Note: SCO2785 CAB87222.1 SCC105.16 SCO2785 SCC105.16, hypothetical protein, len: 595 aa; similar to SW:RHSF_RHIME (EMBL:AF110737) Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhsF, 601 aa; fasta scores: opt: 1094 z-score: 1325.6 E(): 0; 32.4% identity in 592 aa overlap and to TR:P94255 (EMBL:U61153) Bordetella bronchiseptica AlcC, 618 aa; fasta scores: opt: 2037 z-score: 2470.2 E(): 0; 51.5% identity in 592 aa overlap
Product:conserved hypothetical protein
db_xref:GI:7544049, GOA:Q9L069, InterPro:IPR007310, UniProtKB/TrEMBL:Q9L069
Conserved Domains
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Marchler-Bauer A et al (2007) CDD: a conserved domain database for interactive domain family analysis. Nucleic Acids Res. 35: D237-40
Publications
  1. Yang J, Banas VS, Rivera GSM, Wencewicz TA. 2023. Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis. ACS chemical biology 18(6):1266-1270. Abstract in PubMed
  2. Yang J, Banas VS, Patel KD, Rivera GSM, Mydy LS, Gulick AM, Wencewicz TA. 2022. An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD. The Journal of biological chemistry 298(8):102166. Abstract in PubMed
  3. Hoffmann KM, Kingsbury JS, March NL, Jang Y, Nguyen JH, Hutt MM. 2022. Chemoenzymatic Synthesis of Select Intermediates and Natural Products of the Desferrioxamine E Siderophore Pathway. Molecules (Basel, Switzerland) 27(19):. Abstract in PubMed
  4. Hoffmann KM, Goncuian ES, Karimi KL, Amendola CR, Mojab Y, Wood KM, Prussia GA, Nix J, Yamamoto M, Lathan K, Orion IW. 2020. Cofactor Complexes of DesD, a Model Enzyme in the Virulence-related NIS Synthetase Family. Biochemistry 59(37):3427-3437. Abstract in PubMed
  5. Ronan JL, Kadi N, McMahon SA, Naismith JH, Alkhalaf LM, Challis GL. 2019. Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 373(1748):. Abstract in PubMed
  6. Hagihara R, Katsuyama Y, Sugai Y, Onaka H, Ohnishi Y. 2018. Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis. The Journal of antibiotics 71(11):911-919. Abstract in PubMed
  7. Telfer TJ, Codd R. 2018. Fluorinated Analogues of Desferrioxamine B from Precursor-Directed Biosynthesis Provide New Insight into the Capacity of DesBCD. ACS chemical biology 13(9):2456-2471. Abstract in PubMed
  8. Telfer TJ, Gotsbacher MP, Soe CZ, Codd R. 2016. Mixing Up the Pieces of the Desferrioxamine B Jigsaw Defines the Biosynthetic Sequence Catalyzed by DesD. ACS chemical biology 11(5):1452-62. Abstract in PubMed
  9. Rungin S, Indananda C, Suttiviriya P, Kruasuwan W, Jaemsaeng R, Thamchaipenet A. 2012. Plant growth enhancing effects by a siderophore-producing endophytic streptomycete isolated from a Thai jasmine rice plant (Oryza sativa L. cv. KDML105). Antonie van Leeuwenhoek ():page info not available. Abstract in PubMed
  10. Kadi N, Oves-Costales D, Barona-Gomez F, Challis GL. 2007. A new family of ATP-dependent oligomerization-macrocyclization biocatalysts. Nature chemical biology 3(10):652-6. Abstract in PubMed